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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma
doi: 10.3389/fphar.2022.1097197
Figure Lengend Snippet: CDK4/6 inhibitor and EGFR inhibitor increase MHC-I expression by targeting E2F1/SEC61G axis. (A) “Transcription Factor Target” analysis for 2275 co-expressed genes related to SEC61G in HNSCC (Head and Neck Squamous Cell Carcinoma (TCGA, Firehose Legacy)) through webgestalt approach. (B) The correlation between the expression of SEC61G and EGFR in HNSC normal and HNSC tumor based on TCGA-HNSC database. (C) Combination Palbociclib and Cetuximab in Patient-Derived Tumor Xenograft (PDX) model related to hypopharyngeal squamous cell carcinoma. Hypopharyngeal cancer PDX models were treated with control, Palbociclib (100 mg/kg/day), Cetuximab (1 mg/week) or Cetuximab plus Palbociclib for 28 days (n = 6 per group). The growth curves of xenografts are shown. After 28 days, the mice were killed, and tumors were dissected, weighed and photographed. One-way ANOVA and Tukey’s multiple comparisons test. * p < .05, ** p < .01, *** p < .001. Pal, Palbociclib; Cet, Cetuximab; ns, not significant. (D) Immunohistochemistry staining of E2F1, SEC61G, and HLA class I ABC (MHC-I) in PDX models after treatments. Pal, Palbociclib treatment mouse; Cet, Cetuximab treatment mouse; Pal + Cet, Palbociclib plus Cetuximab treatment mouse.
Article Snippet: SEC61G (11147-2-AP) and
Techniques: Expressing, Derivative Assay, Control, Immunohistochemistry, Staining
Journal: iScience
Article Title: Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance
doi: 10.1016/j.isci.2023.107691
Figure Lengend Snippet: List of metal-labeled antibodies used for mass cytometry
Article Snippet:
Techniques:
Journal: iScience
Article Title: Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance
doi: 10.1016/j.isci.2023.107691
Figure Lengend Snippet:
Article Snippet:
Techniques: Transplantation Assay, Recombinant, Staining, Cell Isolation, Software, Cytometry, Flow Cytometry